This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

French virologist and Nobel Prize winner Luc Montagnier reflects on the discovery of HIV, discusses disappointments and lessons learned along the way and the possibility of a vaccine, and gives advice for future AIDS researchers.

Interview with George Louis, Professor and Director at the division of Vaccine and Research at the Initiative of Human Virology (IHV) in Baltimore. He talks about the current HIV vaccine trials and reflects on the future.

Steve Gold, professor at John Hopkins University in the Department of Biological Chemistry, talks about the paradigms of the HIV/AIDS research fields.