French virologist and Nobel Prize winner Luc Montagnier reflects on the discovery of HIV, discusses disappointments and lessons learned along the way and the possibility of a vaccine, and gives advice for future AIDS researchers.

Sten Vermund from University of Alabama reflects on the history of the global AIDS epidemic and his involvement in the field as a young scientist in the 80's. He discusses the social and economic factors of HIV/AIDS, such as stigma, poverty and the drug industry.