French virologist and Nobel Prize winner Luc Montagnier reflects on the discovery of HIV, discusses disappointments and lessons learned along the way and the possibility of a vaccine, and gives advice for future AIDS researchers.

This film is about the global AIDS situation. The film starts in Europe and the United States and ends up in Zimbabwe and Uganda. It tells about the global disparities of drug access, but also about the successful HIV and AIDS responses of Thailand, Cambodia and Uganda.