This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Second and last part of the interview with UNAIDS coordinator Tony Lisle. Here he talks about the UNAIDS leadership and community-based work targeting male sex workers. He also explains why it is particularly difficult to reach out to male sex workers.

Interview with Moises who has been working with HIV prevention since 2000. Here he tells about the Mexican NGO AcciónH and the condom promotion they do in gay bars in Mexico City.

Young AIDS activist Ricardo Baruch talks about the international collaboration of youth activists and the AIDS situation in Mexico for LBGT persons and women in rural areas and developing countries. He also reflects on the International AIDS Conference.

First part of the interview with the American AIDS activist and founder of Project Inform, Martin Delaney, in 2006. He talks about the HIV/AIDS policy of the current and previous American Presidents, and reflects on his experiences of the start of AIDS in the 80's.

Lars Olof Kallings talks about the global AIDS situation and what the international community can do. He reflects on the role of men, women and young people in the fight against AIDS, and stresses the importance of activists and voluntary organizations.