Staffan Hildebrand returns to Australia, where he started his project of documenting the AIDS epidemic in 1988, and to Cambodia where he first arrived in 1998. He interviews some of the scientists and activists who he met back then and displays some footage from the archive.

Mary-Jane Matsolo visits a traditional healer and talks about their important role in the fight against HIV and AIDS. She says that traditional healers are often more trusted than conventional health personnel, and that they are often well educated in HIV and AIDS.

XIX International AIDS Conference. Paul Nsubuga Semugoma from the Global Forum on MSM and HIV, talks about the situation of men who have sex with men in Uganda and how stigma and discrimination interferes with the work to prevent HIV and end AIDS.

XVII International AIDS Conference in Mexico City. Panel session on comprehensive sex education targeting youth, and on how to integrate sexual and reproductive health and rights in the counseling of young people living with HIV. Chair of session is Lennart Hjelmåker.

Professor Sikhamani Rajasekaran, Supervisor of the Tambaram Hospital in Chennai, talks about the HIV/AIDS outbreak in India, the prevalence of TB co-infection and the services at Tambaram Hospital as well as the need for second-line antiretroviral treatment options.

Dr Ingrid van Beek from the Sydney Medically Supervised Injecting Centre (MSIC), a program offering HIV testing, counseling, needle-exchange and methadone programs. She talks about the challenges and successes of the Australian AIDS response.

Interview with Agneta Dreber from Folkhälsomyndigheten (National Institute of Public Health) in Sweden. She talks about the Swedish HIV/AIDS situation, about sexuality education in schools and HIV/AIDS education in workplaces.