Daria Hazuda from MSD explains the virology of HIV and talks about the past clinical studies on ARV, in particular integrase inhibitors, which she has been involved in. She also reflects on HIV as an exceptional virus and how to influence a new generation of HIV researchers.

Interview with Daniel Tarantola, Professor of Health and Human Rights at University of New South Wales in Sydney. He tells about his work in expanding health care services in several African countries, starting in the early 1970's and the time when he entered the HIV field.

This is the third part of the interview with Dr Anthony Fauci. Here he talks about the American AIDS movement in the early 80's with activists such as the writer Larry Kramer in the frontline, and the time when he invited the leading activists up to his office.

First part of the interview with the American AIDS activist and founder of Project Inform, Martin Delaney, in 2006. He talks about the HIV/AIDS policy of the current and previous American Presidents, and reflects on his experiences of the start of AIDS in the 80's.

The Swedish Writer Steve Sjöquist is interviewed about his life with HIV, the HIV situation in Sweden and the rest of the world and his views on the future of the epidemic.

French virologist and Nobel Prize winner Luc Montagnier reflects on the discovery of HIV, discusses disappointments and lessons learned along the way and the possibility of a vaccine, and gives advice for future AIDS researchers.

Sten Vermund from University of Alabama reflects on the history of the global AIDS epidemic and his involvement in the field as a young scientist in the 80's. He discusses the social and economic factors of HIV/AIDS, such as stigma, poverty and the drug industry.

Annual HIV research conference arranged by IHV. Dr Robert Gallo holds a lecture on the history of medical research on human retroviruses. He also talks about the early discoveries of t-cell leukemia in Japanese patients, which led to the discovery of HTLV-1.

David Klatzmann is a french immunologist who has been working in an AIDS group in France since 1981. He talks about the discoveries that CD4-antigens function as receptors for the HIV virus and explains the structure of this relationship in detail.

Luc Montagnier talks about the complex virology of HIV which makes the AIDS vaccine development so difficult. He also talks about the economic and cultural advantages of using traditional medicine as a part of the ARV therapy in developing countries.

Opening of the Cent Gardes Conference in Annecy in 2002. Speeches by the Director of Fondation Mérieux, Alain Mérieux, and participants from other institutions working on HIV vaccines. The film maker Staffan Hildebrand holds a speech about Face of AIDS.

The primary focus of this documentary is on the history of how the AIDS epidemic started in San Francisco, Los Angeles and New York in 1981. Many different stories are told about people affected or surrounded by HIV and AIDS in the early years of the epidemic.