This film tells the US story of the AIDS epidemic starting in the early 1980's. Scientists and activists, both pioneers and youths of today, talk about research, prevention, treatment and care. They also discuss stigma, homophobia and poverty as closely related to HIV and AIDS.

Interview with Daniel Tarantola, Professor of Health and Human Rights at University of New South Wales in Sydney. He tells about his work in expanding health care services in several African countries, starting in the early 1970's and the time when he entered the HIV field.

Young AIDS activist Ricardo Baruch talks about the international collaboration of youth activists and the AIDS situation in Mexico for LBGT persons and women in rural areas and developing countries. He also reflects on the International AIDS Conference.

Mr Subbarao is secretary of state for health in the Tamil Nadu Government in Chennai. In this interview he talks about the educational and medical work lead by the government. He talks particularly about empowering and educate women about HIV prevention.